The business world is being reshaped by entrepreneurs who aren’t afraid to challenge the status quo and break boundaries. The Top 10 Disruptive Entrepreneurs of 2025 highlights individuals who are pushing industries forward with innovative ideas and strategies that challenge traditional models. These entrepreneurs are not only redefining their fields but are also leading transformative change that will have a lasting impact on the way business is done in the future. Their bold approach and visionary thinking are setting the stage for a new era of entrepreneurship.
Michael Lissack
Michael Lissack is a thought leader in the field of science and research, advocating for a more responsible and reflective approach to scientific practice. As the founder and director of Second Order Science Foundation, he is challenging the status quo of ‘sloppy science,’ encouraging researchers to pause and reflect on their work, and ensuring that scientific inquiry is guided by ethics and integrity.
Michael’s vision is grounded in his extensive academic and professional background. He has served as the president of the American Society for Cybernetics and has worked with organizations across various sectors, including healthcare, finance, and education. In 1994, as a managing director at Smith Barney, he exposed a yield-burning scandal, leading to settlements of over $200 million.
A vocal advocate for responsible AI development, Michael recognizes technology’s critical role in shaping the future of science. His commitment to ethical practices is further demonstrated through his endowment of professorships in Social Responsibility and Personal Ethics at Williams College and the University for Humanistics in the Netherlands.
Michael has co-authored papers on the ethical implications of AI and its potential to address sustainability challenges. His ongoing projects include writing two books: MisUsed Tools: Science’s Problem with LLMs and Questioning Understanding, Understanding Questioning, both of which aim to promote ethical practices in science and technology.
Through his foundation and personal efforts, Michael Lissack is helping to reshape the future of science, advocating for an approach that values integrity, reflection, and responsible inquiry above all else.
Dame Brigitte Kruse
From a humble garage to commanding global stages, Dame Brigitte Kruse has redefined the auction world, breaking barriers at every turn. As the founder of Kruse GWS Auctions, Inc., she has become a globally renowned auctioneer for celebrities, royal families, museums, and elite collectors. Notably, she holds the distinction of being the first auctioneer knighted by a Royal Family, solidifying her unmatched legacy.
Dame’s story is about more than just professional milestones; it’s a testament to purpose-driven leadership. A passionate advocate for autism awareness, she has helped raise millions for Autism Research, St. Jude’s, and Steven Tyler’s Janie’s Fund. Her philanthropic reach extends further, as she collaborates with lawmakers to champion constitutional and civil rights.
Kruse GWS Auctions leads the way in innovation, conducting livestreamed auctions for over 15 years and appraising assets from traditional antiques to cutting-edge NFTs. Operating from offices in Florida, Dubai, and Vietnam, the company’s global presence has made it the premier choice for private collectors, celebrities, and royalty.
In February, Kruse GWS Auctions will host an exclusive auction for the Royal Family of Italy, offering extraordinary treasures that are sure to captivate collectors worldwide. Beyond its operational success, the company channels its expertise into charitable causes, making a tangible impact that resonates far beyond the auction room.
Dame’s groundbreaking achievements don’t stop there. She made history as the first woman auctioneer to set a Guinness World Record for the largest personal abandoned property auction, cementing her status as a trailblazer in her field.
All in all, Dame Brigitte Kruse proves that success is even greater when it serves a higher purpose.
Custom Accounting CPA
When it comes to tax planning, Custom Accounting CPA has redefined the game by shifting the focus from compliance to strategy. Unlike traditional CPA firms that focus on filing and retrospective data, Custom Accounting CPA empowers clients with forward-thinking tax reduction plans designed to save them thousands—if not hundreds—every year.
Specializing in serving successful business owners with annual revenues between $1 million and $10 million, as well as high-net-worth individuals in the medical and entertainment industries, Custom Accounting CPA takes a personalized approach. Their goal? To ensure clients pay the absolute minimum in taxes legally, by implementing proven strategies.
Founded by Natalya Grigoriev in 2009, the firm grew from humble beginnings into a recognized leader in the tax planning space. Backed by Certified Tax Coach and Certified Tax Planner credentials, Custom Accounting CPA has earned accolades as one of Brooklyn’s Top Accounting Firms by Expertise.com, Clutch, and LocateNearMe. But it’s not just awards that set them apart—it’s the results. Many clients experience six-figure savings on their tax bills annually, a testament to the firm’s unwavering dedication to financial optimization.
The firm also offers a bold guarantee: if their strategies don’t save clients at least the amount invested in their services, they refund the difference. It’s a promise rooted in confidence and the proven success of their methods.
Beyond helping clients save, Custom Accounting CPA is committed to making an impact. By educating business owners through social media and other platforms, they raise awareness about the importance of proactive tax planning. Their dedication extends to strengthening economic stability within their community by empowering clients to achieve financial freedom.
Tim Dillon
With over 30 years of experience at the forefront of technology, Tim Dillon has solidified his status as one of the most influential figures in the tech industry—his accomplishments over these decades are nothing short of extraordinary.
Tim’s journey began in 1993 when he co-founded Accelerated Media, one of the first companies to design websites. This early venture positioned him as a digital pioneer. His expertise quickly caught Microsoft’s attention, where he helped develop DirectX 1.0 and Windows Media Player, further cementing his impact on the tech world.
Tim is also widely credited as the inventor of Live Mobile Sports Betting and the innovator behind MicroBetting, a concept that allows fans to place bets on real-time events during sports games. This groundbreaking innovation has revolutionized sports betting, providing fans with exciting new ways to engage with their favorite sports.
The patents held by You Call The Play Inc. (YCTP) are highly valuable due to their innovative and industry-defining technologies. Sportsbooks that utilize technologies such as MicroBetting, live in-game wagering, and dynamic betting odds need to obtain a license from You Call The Play Inc. Based on extensive market analysis and the widespread adoption of their technologies, the collective value of YCTP’s patents is estimated to be between $3 billion and $5 billion.
In 2014, Tim co-founded 206 Sports Group, representing athletes like Super Bowl Champion Russell Wilson, combining technology and sports to create fresh branding opportunities. This Spring, Tim is launching an ICO for Sports Fan Crypto, offering fans exciting new ways to connect with the sports they love.
Tim’s inventive spirit continues to drive change across industries, leaving a lasting mark on tech, sports, and beyond.
Jenny Ocampo
Jenny Ocampo (also known as Jenny Ocampo-Cole) is a woman who wears many hats, each with grace, purpose, and a steadfast commitment to making a difference. As an entrepreneur, human resources expert, certified life coach, and a proud and loving mom to Justine, Jenny’s life is a testament to resilience, dedication, and the power of diligence, faith, love and the right sense of self- efficacy.
In 1998, Jenny founded Royalty Human Resources Training and Development Company (RoyaltyHRTDCo), and since then, she has been a beacon of inspiration for individuals and organizations alike. Through her company, Jenny has helped countless individuals and professionals unlock their full potential, providing training and coaching that inspires personal growth and leadership excellence.
With a degree in Political Science, master’s level studies in Public Administration, and additional training in law, management, language, and culture, Jenny brings a diverse and deep knowledge base to her work. Her company offers a range of services—personal and leadership development, effective communication, etiquette training, and life coaching—all designed to foster a culture of excellence in personal and professional growth.
What truly sets Jenny apart, however, is her lived experience. Having faced personal challenges, including widowhood, divorce, and single parenthood, Jenny understands firsthand the importance of resilience. She draws from her own journey to connect with her clients, providing the guidance and inspiration they need to navigate their own obstacles.
Jenny’s efforts have earned her recognition in major outlets like USA News, Digital Journal, and other prominent platforms. Through RoyaltyHRTDCo, she continues to hone, rebuild, train, coach and empower individuals from all walks of life, proving that personal and professional success is always within reach.
From Jenny, we learn a valuable lesson: it’s not how you fall down, but how you rise that defines you.
Dr. Xenia Barnes
Dr. Xenia Barnes is dedicated to transforming trauma into triumph. As a social and behavioral scientist, leadership coach, and speaker, she empowers individuals and organizations to break the cycle of trauma. Her “Trauma-to-Triumph Transformation Model” combines cutting-edge research, cultural sensitivity, and practical tools to support healing and growth.
What sets Dr. Xenia apart is her ability to bridge theory and practice in a way few others can. While many in the field are rooted in academic research or theoretical frameworks, Dr. Xenia ensures that her methods are deeply grounded in the human experience. Her approach doesn’t stop at the page—it’s about real-world applications that resonate with survivors, healthcare professionals, and community advocates. By equipping people with the tools and knowledge needed to navigate the complexities of trauma, she fosters resilience and strength at both individual and collective levels.
Dr. Xenia’s contributions to the field have earned her prestigious recognition, including the Black Excellence Lifetime Achievement Award and the Presidential Lifetime Achievement Service Award. But it is the lives she has transformed that speak the loudest. Through her work, she has helped countless individuals and communities move from pain to empowerment, turning heartbreak into hope.
Her dedication to trauma recovery and leadership development continues to inspire, and she remains at the forefront of the movement to create healthier, more resilient communities. Dr. Xenia’s work is not just about recovery; it’s about creating lasting change that empowers people to overcome adversity and live fulfilling lives.
Robert Nappi
Robert Nappi, the mind behind Eat Figo, is a self-made entrepreneur whose journey is anything but ordinary. After long hours working as an engineer, Robert found himself exhausted not only by his job but also by the daily grind of cooking. The solution? He created Eat Figo—an automated kitchen appliance that makes meal prep effortless, all controlled by a few taps on a smartphone.
Robert’s entrepreneurial spirit has always been there, even from a young age. He’s always been driven to find solutions, and his knack for innovation led him to realize a major gap in the market: busy people need a smarter, simpler way to prepare meals. After years of frustration with spending his evenings cooking after a long day at the office, Robert knew there had to be a better way.
That’s where Eat Figo’s comes in. The beauty of this product is its simplicity and efficiency. What began as a solution to Robert’s own problem quickly grew into a revolutionary product. Within months, Eat Figo became a favorite among busy professionals, and its success opened new doors for collaboration with meal-prep companies.
Robert’s vision now extends beyond just an appliance—he’s committed to reshaping the meal-prep landscape, helping others save time while enjoying fresh, home-cooked meals. With Eat Figo, Robert has shown what true entrepreneurship looks like—identifying a challenge, taking risks, and creating a product that changes lives for the better.
Robert Nappi’s journey is proof that innovation, hard work, and dedication can lead to groundbreaking success.
Jeanne M. Sullivan
Meet Jeanne M. Sullivan, a visionary whose career showcases the boundless possibilities of passion, innovation, and impact. With decades of experience in venture capital, Jeanne has shattered barriers and guided countless entrepreneurs toward success.
Jeanne’s journey started in marketing, where she gained a unique blend of tech and business expertise at leading companies like AT&T, Bell Labs, and a large advertising agency. As one of the few female general partners in venture capital at the time, Jeanne made a significant mark in 1999 when she co-founded a tech fund that managed an impressive $400 million.
In 2014, Jeanne embarked on a new career chapter, stepping away from the fund in a planned exit to pursue other passions. This included speaking engagements, traveling across Europe, and discovering her next passion: the cannabis industry. When New York passed the Compassionate Care Act, Jeanne jumped into the field and became a pioneer for change, especially for women. Her efforts earned her recognition as a Business Insider Rising Star in Cannabis in 2018 and she was honored at the most recent MJBizCon Women’s Leadership Awards in December 2024 for her leadership in the sector.
But Jeanne’s impact goes beyond her achievements. She is deeply committed to empowering business owners, helping them refine their pitch, secure investors, and shape their vision. Her dynamic speaking style, infused with humor and wisdom, leaves a lasting impression on her audiences.
Now, Jeanne continues her mission to advocate for sustainability and women-led businesses while expanding her advisory work US and in Europe. She remains focused on promoting meaningful change and guiding the next generation of leaders.
Dr. Saira Ahmed, MD
ProSkin Doctor, founded by Dr. Saira Ahmed, a board-certified physician with over 15 years of experience, is redefining how people access high-quality skincare. Recognized as a Top Doc in New Jersey for several years, Dr. Saira brings unmatched expertise, compassion, and a deep commitment to excellence.
Dr. Saira launched ProSkin Doctor with one clear vision: to provide a convenient, one-stop shop for medical-grade skincare products. She recognized the confusion and hesitation many people feel when faced with countless options and the fear of choosing the wrong product. Her platform was designed to eliminate those worries and empower individuals to achieve their dream of flawless skin with products backed by science. After all, the desire for perfect skin and beauty often comes with uncertainty, but ProSkin Doctor exists to remove those doubts and make confident choices possible for everyone.
ProSkin Doctor’s mission doesn’t stop at skincare. Dr. Saira is dedicated to expanding her product line by partnering with only the most reputable brands while maintaining uncompromising quality standards. Beyond that, she ensures that a portion of the company’s proceeds is donated annually to local charities—because the community is what makes everything possible, and giving back is at the heart of her mission.
With her expertise, compassion, and dedication to helping others, Dr. Saira Ahmed has turned ProSkin Doctor into more than just an online store—it’s a trusted resource for effective skincare solutions. Through top-quality products and charitable initiatives, ProSkin Doctor is making a lasting impact, solidifying Dr. Saira as a trailblazing entrepreneur and a force for good in the community.
Dr. Kawana Jeffer Williams
In a world where health disparities persist, Dr. Kawana Jeffer Williams shines as a trailblazer in integrating psychology and healthcare innovation to create equitable solutions for all. As a Health Psychologist and Healthcare Innovator, Dr. Williams focuses on transforming the healthcare experience by addressing systemic gaps, enhancing patient outcomes, and improving lives on a large scale.
At the core of her mission is Well-Konnect Healthcare Services, an innovative firm reshaping healthcare delivery. By focusing on underserved communities, Well-Konnect provides equitable access to care, prioritizing underserved populations with services that go beyond traditional treatment. Through personalized health plans and comprehensive care management, the firm ensures chronic disease patients receive the support they need to thrive. Dr. Kawana’s leadership also drives their preventive services, empowering individuals to take charge of their health and fostering healthier, more equitable futures for all.
Driven by Dr. Kawana Jeffer Williams, Well-Konnect’s impact goes beyond patient care by actively empowering healthcare professionals. The firm offers advanced training, fosters collaborative research, and provides educational opportunities, cultivating a network of skilled providers committed to driving innovation and excellence in healthcare.
Dr. Kawana’s vision is deeply rooted in community engagement and equity. Through her leadership, Well-Konnect bridges gaps in healthcare access, fostering partnerships that benefit both professionals and patients. Her work embodies the principles of compassion, innovation, and inclusivity, influencing healthcare delivery at every level.
By transforming the way healthcare is delivered and experienced, Dr. Kawana Jeffer Williams and Well-Konnect are not just reshaping lives—they’re shaping the future of healthcare itself, defining a movement toward health equity and excellence for all.